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For the first time, highly sensitive electrochemical biosensor based on SiO₂-based hairy particles with a grafted PDMAEMA polymer brush containing a quantifiable and large amount of immobilized Laccase is reported. The fabricated biosensor exhibited a sensitivity of 0.14 A·M⁻¹, a limit of detection (LOD) of 0.1 µM, and a detection range of 0.3–750 µM, which significantly outperforms most comparable systems.

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https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/adfm.202507589