4D Biofabrication
We develop methods for 3D bioprinting of novel polymeric biomaterials as well as polymer-cell structures with advaced properties. Particular focus is printing of stimuli-responsive polymers and hydrogels. We use fused filament printing, extrusion printing of hydrogels, ink-jet printing as well as stereolithography.
Our particular focus is 4D biofabrication, which is fabrication of cellular structures by shape-transformation of 3D objects. We pioneered fabrication of 4D biofabrication using most important biodegradable polymers, which are widely used in tissue engineering, such as gelatin, alginate and hyaluronic acid.
Cardiomyocytes in self-rolled polymer tube
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Kitana, Waseem; Apsite, Indra; Hazur, Jonas; Boccaccini, Aldo R.; Ionov, Leonid
4D Biofabrication of T-Shaped Vascular Bifurcation
in Advanced Materials Technologies volume 8 (2023) issue 1
doi:10.1002/admt.202200429 ...
Trujillo-Miranda, Mairon; Apsite, Indra; Rodríguez Agudo, Jose A.; Constante Ibarra, Gissela Katherine; Ionov, Leonid
4D Biofabrication of Mechanically Stable Tubular Constructs Using Shape Morphing Porous Bilayer ...
in Macromolecular Bioscience volume 23 (2023) issue 1
doi:10.1002/mabi.202200320 ...
Constante Ibarra, Gissela Katherine; Apsite, Indra; Alkhamis, Hanin; Dulle, Martin; Schwarzer, Madeleine; Caspari, Anja; Synytska, Alla; Salehi, Sahar; Ionov, Leonid
4D Biofabrication Using a Combination of 3D Printing and Melt-Electrowriting of Shape-Morphing ...
in ACS Applied Materials & Interfaces volume 13 (2021) issue 11. - page 12767-12776
doi:10.1021/acsami.0c18608 ...
Uribe Gómez, Juan Manuel; Posada Murcia, Andrés; Shukla, Amit; Ergin, Mert; Constante Ibarra, Gissela Katherine; Apsite, Indra; Dulle, Martin; Schwarzer, Madeleine; Caspari, Anja; Synytska, Alla; Salehi, Sahar; Ionov, Leonid
Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing a ...
in ACS Applied Bio Materials volume 4 (2021) issue 2. - page 1720-1730
doi:10.1021/acsabm.0c01495 ...
Apsite, Indra; Constante Ibarra, Gissela Katherine; Dulle, Martin; Vogt, Lena; Caspari, Anja; Boccaccini, Aldo R.; Synytska, Alla; Salehi, Sahar; Ionov, Leonid
4D biofabrication of fibrous artificial nerve graft for neuron regeneration
in Biofabrication volume 12 (2020) issue 3
doi:10.1088/1758-5090/ab94cf ...
Apsite, Indra; Uribe Gómez, Juan Manuel; Posada Murcia, Andrés; Rosenfeldt, Sabine; Salehi, Sahar; Ionov, Leonid
4D biofabrication of skeletal muscle microtissues
in Biofabrication volume 12 (2020) issue 1
doi:10.1088/1758-5090/ab4cc4 ...
Apsite, Indra; Stoychev, Georgi; Zhang, Weizhong; Jehnichen, Dieter; Xie, Jin; Ionov, Leonid
Porous stimuli-responsive self-folding electrospun mats for 4D biofabrication
in Biomacromolecules volume 18 (2017) issue 10. - page 3178-3184
doi:10.1021/acs.biomac.7b00829 ...
Stroganov, Vladislav; Pant, Jitendra; Stoychev, Georgi; Janke, Andreas; Jehnichen, Dieter; Fery, Andreas; Handa, Hitesh; Ionov, Leonid
4D Biofabrication : 3D Cell Patterning Using Shape-Changing Films
in Advanced Functional Materials vol. 28 (2018)
doi:10.1002/adfm.201706248 ...
Kirillova, Alina; Maxson, Ridge; Stoychev, Georgi; Gomillion, Cheryl T.; Ionov, Leonid
4D Biofabrication Using Shape-Morphing Hydrogels
in Advanced Materials (2017)
doi:10.1002/adma.201703443 ...
Apsite, Indra; Stoychev, Georgi; Zhang, Weizhong; Jehnichen, Dieter; Xie, Jin; Ionov, Leonid
Porous stimuli-responsive self-folding electrospun mats for 4D biofabrication
in Biomacromolecules vol. 18 (2017) issue 10. - pp. 3178-3184
doi:10.1021/acs.biomac.7b00829 ...
Stroganov, Vladislav; Zakharchenko, Svetlana; Sperling, Evgeni; Meyer, Anne K.; Schmidt, Oliver G.; Ionov, Leonid
Biodegradable Self-Folding Polymer Films with Controlled Thermo-Triggered Folding
in Advanced Functional Materials vol. 24 (2014) issue 27. - pp. 4357-4363
doi:10.1002/adfm.201400176 ...
Zakharchenko, Svetlana; Puretskiy, Nikolay; Stoychev, Georgi; Waurisch, Christian; Hickey, Stephen G.; Eychmüller, Alexander; Sommer, Jens-Uwe; Ionov, Leonid
Stimuli-responsive hierarchically self-assembled 3D porous polymer-based structures with aligned pores
in Journal of Materials Chemistry B vol. 1 (2013) issue 13. - pp. 1786-1793
doi:10.1039/C2TB00231K ...
Zakharchenko, Svetlana; Sperling, Evgeni; Ionov, Leonid
Fully Biodegradable Self-Rolled Polymer Tubes : a Candidate for Tissue Engineering Scaffolds
in Biomacromolecules vol. 12 (2011) issue 6. - pp. 2211-2215
doi:10.1021/bm2002945 ...