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Faculty of Engineering Science

Biofabrication – Prof. Dr. Leonid Ionov

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3D Biofabrication

Sequention biofab

Biofabrication, a multidisciplinary field that applies multitude of technologies, such as 3D (bio)printing for the fabrication of biologically relevant constructs. These biofabrication technologies aim at replicating the complex architecture of human tissues and organs. Recently, biofabrication technologies have gained much attention in many fields such as the fields of tissue engineering and regenerative medicine on the basis of their potential of biofabricating tissue-like constructs that would resolve the matter of donor organ and tissue shortage worldwide.

In this work, a novel approach for the biofabrication of composite multilayered bioink-nanofibers construct is reported. For this, the 3D (bio)printing technology is integrated into the fiber spinning technology for the fabrication of composite multilayered constructs. Using this setup, the biofabrication of bioink-nanofibers constructs is possible, which aims at mimicking the complex architecture of extracellular matrix (ECM) of many tissues. The interaction of cells in the different bioinks with the highly aligned nanofibers shows a preferred orientation of cell body along the fibers main direction. 

Selected publications

Kitana, Waseem; Levario Diaz, Victoria; Cavalcanti-Adam, Elisabetta Ada; Ionov, Leonid
Biofabrication of Composite Bioink-Nanofiber Constructs : Effect of Rheological Properties of B ...
in Advanced Healthcare Materials (2023)
doi:10.1002/adhm.202303343 ...

Uribe Gómez, Juan Manuel; Schönfeld, Dennis; Posada Murcia, Andrés; Roland, Michel-Manuel; Caspari, Anja; Synytska, Alla; Salehi, Sahar; Pretsch, Thorsten; Ionov, Leonid
Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch-Spun Poly(Ester-urethane) El ...
in Macromolecular Bioscience volume 22 (2022) issue 4
doi:10.1002/mabi.202100427 ...

Uribe Gómez, Juan Manuel; Posada Murcia, Andrés; Shukla, Amit; Alkhamis, Hanin; Salehi, Sahar; Ionov, Leonid
Soft Elastic Fibrous Scaffolds for Muscle Tissue Engineering by Touch Spinning
in ACS Applied Bio Materials volume 4 (2021) issue 7. - page 5585-5597
doi:10.1021/acsabm.1c00403 ...

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