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Faculty of Engineering Science

Biofabrication – Prof. Dr. Leonid Ionov

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We develop methods for design of scaffolds, encapsulation of cells and design of micro tissues using stimuli-responive polymers. In one our approach we use polymer bilayers consisting of polymers with different swelling properties. The cells can be either adsorbed on polymer bilayer or encapsulated inside one of the layer. These polymers layers with cells form tube and other structures with cells inside. The tubes can be aligned and assembled together to form scaffolds for tissue engineering.

Cardiomyocytes in self-rolled polymer tube (joint work with Dr. Peter Loskill)

Selected publications

Stroganov, Vladislav; Pant, Jitendra; Stoychev, Georgi; Janke, Andreas; Jehnichen, Dieter; Fery, Andreas; Handa, Hitesh; Ionov, Leonid
4D Biofabrication : 3D Cell Patterning Using Shape-Changing Films
in Advanced Functional Materials vol. 28 (2018) 
doi:10.1002/adfm.201706248 ...

Stroganov, V.; Zakharchenko, S.; Sperling, E.; Meyer, A.K.; Schmidt, O.G; Ionov, L*. Biodegradable self-folding polymer films with controlled thermo-triggered folding, Advanced Functional Materials 2014, 24(27), 4357–4363. DOI: 10.1002/adfm.201400176

Reuther, C.; Tucker, R.; Ionov, L.; Diez, S. Programmable patterning of protein bioactivity by visible light, Nano Letters 2014, 14 (7), 4050–4057. DOI: 10.1021/nl501521q

Zakharchenko, S.; Puretskiy, N.; Stoychev, G.; Waurisch, C.; Hickey, S.G.; Eychmüller, A.; Sommer, J.U.; Ionov, L.* Stimuli-responsive hierarchically self-assembled 3D porous polymer-based structures with aligned pores, Journal of Materials Chemistry B, 2013, 1, 1786-1793. DOI: 10.1039/C2TB00231K

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